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SUMMARY:Chromosomal condensate as a memory machine - Leonid Mirny (Massach
 usetts Institute of Technology)
DTSTART:20231010T084000Z
DTEND:20231010T092000Z
UID:TALK204916@talks.cam.ac.uk
DESCRIPTION:Every cell remembers who it is\, e.g.\, a neuron or a skin cel
 l. This cellular identity is maintained to a great extent by epigenetic me
 mory\, patterns of chemical modifications of DNA and histones along the ge
 nome.\nWe ask how cells can maintain the epigenetic memory for hundreds of
  generations. We modeled joint dynamics of chromosomes and histone marks: 
 loss and spreading of marks\, and refolding of chromosomes through the cel
 l cycle. A surprising analogy between the spreading of histone marks and t
 he spreading of a pandemic helped to identify factors that provide robust 
 memory. We further found a parallel between epigenetic memory and an assoc
 iative memory in the neural network. Our analysis shows that operation of 
 chromatin as an epigenetic memory device requires folding of the marked re
 gion into the dense and spatial segregated condensate\, enzyme limitation\
 , and spatial spreading of the marks. Our findings suggest a functional ro
 le for the phase-separated genome.
LOCATION:Seminar Room 1\, Newton Institute
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