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SUMMARY:The (in)fidelity of human mitochondrial gene expression - Professo
 r Brendan Battersby\, University of Helsinki\, Finland
DTSTART:20231114T150000Z
DTEND:20231114T160000Z
UID:TALK205000@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Human mitochondria possess one of the most simplified genomes 
 in cellular life.  Despite the genome simplicity\, the regulatory mechanis
 ms of mitochondrial gene expression remain significant outstanding biologi
 cal questions.  In my group\, we investigate the quality control of mitoch
 ondrial gene expression\, focusing on post-transcriptional and co-translat
 ional processes\, and how disruptions to these molecular functions manifes
 t into human pathologies.  My goal is to understand how these mechanisms a
 re then integrated with organelle membrane dynamics and function across ce
 ll types.  Our current studies have identified underlying sources of RNA e
 rrors in mitochondrial gene expression and the associated ribosome quality
  control machinery to resolve these aberrations\, and how disruptions to t
 hese processes manifest across diverse cell types and in animal models of 
 mitochondrial dysfunction.  Understanding cell-specific responses to mitoc
 hondrial protein synthesis defects will be a key to elucidate the molecula
 r pathogenesis of human mitochondrial disorders.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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