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SUMMARY:Reverse Phenotyping: towards an integrated (epi)genomic approach t
 o common disease and complex phenotypes - Prof. Stephan Beck\, University 
 College London
DTSTART:20091026T123000Z
DTEND:20091026T133000Z
UID:TALK20503@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:The laboratory has broad interests in the genomics of phenotyp
 ic plasticity in health and disease. In addition to polymorphisms and muta
 tions\, we study epigenetic changes such as DNA methylation and histone mo
 difications that can modulate genome function under exogenous influence. \
 n\nCentral to our research is the development of an integrated systems app
 roach - termed 'reverse phenotyping' - to screen genomes of common disease
 s as well as cancer for genetic\, epigenetic and combinatorial variations.
  The ability to distinguish causal from consequential variations is one of
  the key challenges in biomedical research. Once fully established\, 'reve
 rse phenotyping' can be expected to significantly increase our ability to 
 identify novel and\, in particular\, combinatorial variations causing or c
 ontributing to phenotypic plasticity and thus will provide new targets for
  translation into diagnostics and therapeutics.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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