BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Mechanosensing in the pancreatic cancer microenvironment - Laura M
 achesky (CRUK Beaton Institute\, University of Glasgow)
DTSTART:20231016T120000Z
DTEND:20231016T130000Z
UID:TALK205162@talks.cam.ac.uk
DESCRIPTION:Pancreatic cancer is highly metastatic\, with a 5-year surviva
 l rate of less than 10%.&nbsp\; Tumours are hallmarked by accumulation of 
 highly fibrotic extracellular matrix\, which correlates with poor prognosi
 s and spread to organs such as liver\, lung and peritoneal cavity.&nbsp\; 
 Our aim is to understand the molecular connections between force sensing a
 nd aggressiveness of tumour cells.&nbsp\; We recently discovered a connect
 ion between mechanosensing\, invasive migration and metabolic supply/deman
 d in pancreatic cancer cells.&nbsp\; I will discuss our model for how cell
 s align their cytoskeletal polarity with their metabolic machinery to meet
  the high demands of the cancer microenvironment.&nbsp\; If we can better 
 model and understand this alignment\, we can hope to find new ways to targ
 et the aggressiveness and spread of pancreatic cancer.&nbsp\;\n&nbsp\;
LOCATION:Seminar Room 2\, Newton Institute
END:VEVENT
END:VCALENDAR