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SUMMARY:Phase separation modeling and chromatin reconstruction - David Hol
 cman (CNRS - Ecole Normale Superieure Paris)
DTSTART:20231013T080000Z
DTEND:20231013T084000Z
UID:TALK205240@talks.cam.ac.uk
DESCRIPTION:Phase separated domains (PSDs) are ubiquitous in cell biology\
 , representing nanoregions of high molecular concentration. PSDs appear at
  diverse cellular domains\, such as neuronal synapses but also in eukaryot
 ic cell nucleus\, limiting the access of transcription factors and thus pr
 eventing gene expression.\nWe will present here some properties of PSDs de
 rived from polymer models. Increasing the number of cross-linkers generate
  a polymer condensation\, preventing the access of diffusing molecules. To
  investigate how the PSDs restrict the motion of diffusing molecules\, we 
 estimate the mean residence and first escaping times. Finally\, by computi
 ng the mean square displacement of single particle trajectories\, we can r
 econstruct the properties of PSDs in term of a continuum range of anomalou
 s exponents. To conclude\, PSDs can result from a condensed chromatin\, wh
 ere the number of cross-linkers control the molecular access.
LOCATION:Seminar Room 1\, Newton Institute
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