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SUMMARY:How do chromatin remodelling enzymes reshape chromatin? - Joel Mac
 kay
DTSTART:20230925T110000Z
DTEND:20230925T120000Z
UID:TALK205249@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:Any biological process involving the genome – be it transcri
 ption\, replication or repair – requires the mechanical remodelling of h
 istone-DNA interactions. This remodelling is achieved by sophisticated ATP
 -dependent DNA translocase enzymes. We have set out to determine the mecha
 nism by which one prominent remodeller that is conserved across multicellu
 lar organisms – CHD4 – can move histones relative to DNA. I will descr
 ibe our results to date and the mechanistic and functional insights that t
 hey have provided.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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