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SUMMARY:HONORARY FELLOWS LECTURE - Every breath you take and every move yo
 u make - understanding cellular oxygen sensing mechanisms - Professor Sir 
 Peter Ratcliffe FRS\, Distinguished Scholar\, Ludwig Institute for Cancer 
 Research\, University of Oxford and Clinical Research Director\, Francis C
 rick Institute\, London.
DTSTART:20240306T180000Z
DTEND:20240306T190000Z
UID:TALK205342@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:The maintenance of oxygen homeostasis is a key physiological c
 hallenge\, inadequate oxygen (hypoxia) being a major component of most hum
 an diseases. The lecture will trace insights into human oxygen homeostasis
  from the founding work of William Harvey on the circulation of the blood 
 to the molecular elucidation of a system of oxygen sensing that functions 
 to measure oxygen levels in cells and control adaptive responses to hypoxi
 a. The lecture will outline how the oxygen sensitive signal is generated b
 y a set of ‘oxygen splitting’ enzymes that modify a transcription fact
 or (HIF) to signal for its degradation (and hence inactivation).  It will 
 attempt to illustrate and rationalise the unexpected in biological discove
 ry and discuss the interface of discovery science with the development of 
 medical therapeutics.
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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