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SUMMARY:Milner Special Seminar - Jeong Hun Kim - Jeong Hun Kim\, Seoul Nat
 ional University Hospital and Seoul National University College of Medicin
 e\, Seoul\, Korea
DTSTART:20231002T090000Z
DTEND:20231002T100000Z
UID:TALK205426@talks.cam.ac.uk
CONTACT:Mary-Jane Roebuck
DESCRIPTION:Join us for a Milner Special Seminar hosted by Dr Namshik Han.
  The seminar will include time for Q&A and will be followed by refreshment
 s and networking.\n\nSpeaker: Jeong Hun Kim\,\nSeoul National University H
 ospital and Seoul National University College of Medicine\, Seoul\, Korea\
 n\nTopic: “In vivo genome editing for vision”\n\nAbstract: \nFrom the 
 FDA approval of anti-VEGF aptamer to wet-type age-related macular degenera
 tion (AMD) of choroidal neovascularization\, anti-VEGF aptamer and antibod
 y have been widely used against all kinds of vaso-proliferative retinopath
 y. Actually\, current therapies directed at controlling vascular abnormali
 ties in vaso-proliferative retinopathy target VEGF and can slow the progre
 ssion of these diseases. While the general role of VEGF in development has
  been well described\, the specific function of locally synthesized VEGF i
 n the eye is incompletely understood. Recently\, RNA-guided genome surgery
  using CRISPR-Cas9 nucleases has shown promise for the treatment of divers
 e genetic diseases. Yet\, the potential of such nucleases for therapeutic 
 applications in non-genetic diseases including AMD\, diabetic retinopathy 
 (DR) as well as retinopathy of prematurity (ROP) is largely unexplored. Th
 ose vision-threatening retinopathies such as AMD\, DR\, and ROP are leadin
 g causes of blindness in adults and children\, which is associated with re
 tinal over-expression of\, rather than mutations in\, the VEGFA gene.\n\nH
 erein I would like to provide some my recent experimental results of thera
 peutic applications such as small peptide\, small molecule as well as nano
 particles beyond anti-VEGF antibody. In addition\, some results of in vivo
  genome editing in vision-threatening retinopathy would be provided.\n\nPl
 ease register at: https://milner-special-seminar-october-2023.eventbrite.c
 o.uk
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre 
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