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SUMMARY:Organismal Proteostasis: Collapse in Aging and Rejuvenation Approa
 ches - Prof Rick Morimoto\; Northwestern University 
DTSTART:20231016T130000Z
DTEND:20231016T140000Z
UID:TALK205699@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Rick Morimoto is the Bill and Gayle Cook Professor of Biology 
 and Director of the Rice Institute for Biomedical Research in the Departme
 nt of Molecular Biosciences at Northwestern University. He was trained in 
 the Department of Biochemistry and Molecular Biology at Harvard University
 \, received the Ph.D. in Molecular Biology from The University of Chicago 
 and undergraduate degree in Biology from the University of Illinois in Chi
 cago. His research is broadly on the biology of aging and risk for a large
  class of protein conformational diseases. These include Alzheimer’s dis
 ease\, Frontal Temporal Dementia\, Parkinson’s Disease\, ALS and Traumat
 ic Brain Encephalopathy all of which cause profound molecular damage to th
 e proteome and accumulation of misfolded and aggregated proteins associate
 d with neuronal dysfunction. Dr. Morimoto's laboratory has published over 
 300 papers including three monographs and four books and has received mult
 iple ten year MERIT award grants from the NIH. He is an elected member of 
 the American Academy of Arts and Sciences\, the American Association for t
 he Advancement of Science\, and received the Ordre des Palmes Académiques
  – Commandeur from the French Ministry of Education\, the Fyodor Lynen M
 edal from the German Society of Biochemistry and Molecular Biology\, Fello
 w of the Japanese Society for the Promotion of Science and the Royal Socie
 ty Wolfson Fellowship at the University of Cambridge. He was a founder of 
 Proteostasis Therapeutics\, Inc. to discover small molecule therapeutics f
 or diseases of protein conformation.\n\nOrganismal Proteostasis: Collapse 
 in Aging and Rejuvenation Approaches Rick Morimoto Department of Molecular
  Biosciences\, Rice Institute of Biomedical Research\, Northwestern Univer
 sity\, Evanston\, IL 60201 Proteostasis enables the functional health of t
 he proteome by the dynamic properties of the Proteostasis Network (PN) to 
 ensure that protein synthesis\, folding and assembly\, localization and de
 gradation are robust and resilient. In metazoans\, proteostasis is regulat
 ed by intertissue communication from sensory neurons to the soma through n
 europeptides that regulate the systemic response to heat shock and organis
 mal proteostasis. However\, in aging PN capacity declines and represents a
  primary risk factor for all degenerative diseases. A major contributing f
 actor to the loss of resilience is increased proteome instability which in
  C. elegans occurs early in adulthood programmed by an epigenetic switch f
 rom germline stem cells to somatic tissues at the onset of reproductive ma
 turity. This results in the simultaneous decline of multiple essential ada
 ptive cell stress responses which compromises stress resilience and PN cap
 acity in aging. Our current efforts are to identify the earliest events of
  aging that predict subsequent tissue and organismal failure of proteostas
 is and strategies to rejuvenate the PN for health aging.\n
LOCATION:Kings Hedges Room\, Babraham Research Campus
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