BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Cold temperature delays aging and proteostasis collapse - Prof Da vid Vilchez Guerrero\; CECAD\, University Hospital of Cologne DTSTART:20231017T123000Z DTEND:20231017T133000Z UID:TALK205705@talks.cam.ac.uk CONTACT:Bobbie Claxton DESCRIPTION:David Vilchez is a Professor at the Faculty of Medicine and Fa culty of Mathematics and Natural Sciences of the University of Cologne (Ge rmany). Before joining the University of Cologne\, he was a Postdoc at the University of California\, Berkeley\, USA\, and the Salk Institute for Bi ological Research\, USA. His group is part of the CECAD Excellence Cluster which brings together basic researchers and clinicians to study molecular and cellular mechanisms underlying aging and age-related diseases. David Vilchez's group studies the regulation of protein homeostasis in immortal stem cells and its demise in age-related diseases. His lab also uses the i nvertebrate C. elegans to define regulatory mechanisms of aging and protei n homeostasis at the organismal level.\n\nExtreme low temperatures are det rimental\, but a moderate decrease in body temperature can have beneficial effects for the organism. In fact\, lowering body temperature extends lon gevity in both poikilotherms (for example Caenorhabditis elegans\, Drosoph ila melanogaster\, and distinct fish species) and homeotherms such as rod ents. For instance\, C. elegans lives for a shorter period of time when sh ifted from the standard temperature (20 °C) to warmer temperatures\, wher eas exposure to low temperature (15 °C) induces a remarkable lifespan ext ension. Here I will talk about the effects of moderate cold temperature i n reproductive aging. Moreover\, I will discuss our recent findings on how cold temperature influences proteostasis and its effects on disease-relat ed protein aggregation in worm and human cell models.\n LOCATION:Kings Hedges Room\, Babraham Research Campus END:VEVENT END:VCALENDAR