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SUMMARY:Degron peptides: Cancer mutation hotspots and tools for synthetic 
 biology - Dr Andrew Wood\; University of Edinburgh
DTSTART:20231031T133000Z
DTEND:20231031T143000Z
UID:TALK205708@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Andrew did his PhD in the laboratory of Rebecca Oakey at Kings
  College London working on genomic imprinting. He was then awarded a Sir H
 enry Welcome Fellowship to work with Barbara Meyer at UC Berkeley\, where 
 he helped to develop the early genome editing technologies which paved the
  way for the CRISPR revolution. He started his own laboratory at the MRC H
 uman Genetics Unit in 2014 with a Sir Henry Dale Fellowship and his curren
 t focus is on degrons\, the peptide sequences that govern protein turnover
  kinetics. He leads a cluster in the MRC National Mouse Genetics Network f
 ocused on degron tags and their application in mouse models.\n\nMy laborat
 ory develops genetic technologies to advance our understanding of human di
 sease and therapeutics. This talk will cover two ongoing projects centred 
 on the theme of protein degradation. First\, I will discuss collaborative 
 work using CRISPR saturating mutagenesis to quantify the effect of all pos
 sible missense mutations across the endogenous degron motif of ß-Catenin\
 , which is one of the most frequently mutated regions in the genome of sev
 eral human cancer types. We have integrated these mutational effect scores
  with clinical data to understand the relationship between mutational dive
 rsity\, strength of oncogenic signalling\, tumour – immune interactions 
 and survival. Second\, I will discuss our efforts to adapt synthetic degro
 n tag technology for studying protein function and modelling protein degra
 der drug activity in mice\, which we are undertaking as part of the MRC Na
 tional Mouse Genetics Network.\n
LOCATION:Kings Hedges Room\, Babraham Research Campus
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