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SUMMARY:Genome editing of red cell precursors and Plasmodium falciparum to
  study host-parasite interactions in malaria - Prof Alex Rowe (University 
 of Edinburgh)
DTSTART:20231101T140000Z
DTEND:20231101T150000Z
UID:TALK205792@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Adhesion interactions between _P. falciparum_ infected erythro
 cytes and human cells underlie the pathology of severe malaria. We are usi
 ng CRISPR-Cas9 genome editing to identify the molecules involved in virule
 nce-associated adhesion phenotypes such as rosetting\, the binding of infe
 cted erythrocytes to uninfected ones to form clusters of cells that contri
 bute to microvascular obstruction and malaria pathology. Unpublished data 
 will be presented including editing of an erythroid precursor cell line to
  knockout candidate rosetting receptors\, and reverse genetic studies of t
 he parasite adhesion molecule PfEMP1 to identify key adhesion domains and 
 make modifications such as epitope tags to facilitate future investigation
 s of this diverse and multifunctional protein family 
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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