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SUMMARY:How do RNAs fold\, dynamically? - Julius Lucks\, Northwestern Univ
 ersity
DTSTART:20231019T120000Z
DTEND:20231019T130000Z
UID:TALK205801@talks.cam.ac.uk
CONTACT:Marco Vona
DESCRIPTION:RNAs are central molecules to life\, and are emerging as power
 ful components of biotechnologies. As with all biomolecules\, RNA function
  is intimately related to its structure\, and RNAs can fold into exquisite
 ly sophisticated shapes that bind molecules\, control gene expression\, an
 d even perform catalysis. While we know a great deal about how RNAs fold i
 n a test tube\, we know very little about how RNAs fold inside the cell\, 
 where RNA folding is highly dynamic\, involving the coupling of stochastic
  processes that occur across time scales ranging from microseconds to minu
 tes. In this talk\, I will provide an introduction to the ‘cellular RNA 
 folding problem’\, describe new experimental and computational tools bei
 ng developed to address this problem\, and end by posing some specific que
 stions and challenges to the applied math community. The hope is to spark 
 collaborations that could lead to a solution\, which would create advances
  in our understanding and treatment of disease\, inform the design of new 
 biotechnologies including mRNA vaccines\, and increase our understanding o
 f life itself.
LOCATION:MR15\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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