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SUMMARY:Calcium signalling and mechanochemical modelling in fertilization 
 and embryogenesis - Katerina Kaouri\, Cardiff University
DTSTART:20231113T130000Z
DTEND:20231113T140000Z
UID:TALK205810@talks.cam.ac.uk
CONTACT:Marco Vona
DESCRIPTION:Calcium (Ca2+) signalling is one of the most important mechani
 sms of information propagation in the body. Moreover\, the coupling betwee
 n Ca2+ signalling and mechanical forces plays a crucial role in health and
  disease. In embryogenesis\, this mechanochemical coupling is critical but
  poorly understood\; if it goes wrong embryo malformations occur\, such as
  Spina Bifida and anencephaly. Also\, at fertilization\, similar mechanoch
 emical coupling has been observed\; dramatic Ca2+ waves are coupled to sub
 tle cytoplasmic movements and flows. I am going to present research\, in c
 ollaboration with experimentalists\, that sheds some light into this fasci
 nating Ca2+ signalling world. Our work includes continuum mechanochemical 
 models and cell-based (vertex) models.
LOCATION:MR15\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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