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SUMMARY:Convergent evolution of CO2-fixing liquid-liquid phase separation 
  - Luke Mackinder\, University of York
DTSTART:20240125T121500Z
DTEND:20240125T134500Z
UID:TALK206161@talks.cam.ac.uk
CONTACT:Jake Harris
DESCRIPTION:Approximately one-third of global carbon-fixation occurs in an
  overlooked algal organelle called the pyrenoid. The pyrenoid is a biomole
 cular condensate of the CO2-fixing enzyme Rubisco that enhances carbon-fix
 ation by supplying Rubisco with a high concentration of CO2. Recently we h
 ave characterized pyrenoids across the eukaryotic tree of life enabling: 1
 ) the timing of convergent evolution of pyrenoids in the green lineage to 
 ~260 Mya during the late Permian O2:CO2 maxima\; 2) the demonstration of f
 unctional cross compatibility of pyrenoid assembly spanning 800 My of evol
 ution\; 3) discovery of a protein shell that encapsulates diatom pyrenoids
 \; and 4) identification of a promiscuous pyrenoid assembly protein that c
 an condense plant Rubisco into proto-pyrenoids in vitro and in vivo. Our d
 ata provides insights into the evolution of biomolecular condensation and 
 is guiding the engineering of a pyrenoid into higher plants to enhance cro
 p carbon fixation efficiency.
LOCATION:Large Lecture Theatre\, Department of Plant Sciences
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