BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Multicellular and extracellular matrix dynamics underlying skin mo
 rphogenesis. - Dr. Hironobu Fujiwara\, RIKEN Center for Biosystems Dynamic
 s Research (BDR)\, Kobe\, Japan
DTSTART:20231127T143000Z
DTEND:20231127T153000Z
UID:TALK206230@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:https://us06web.zoom.us/j/82089026611?pwd=L2FyclJFL2lYR0J3SFBD
 bHQyUFp6UT09\n\nAbstract: The interaction between cells and their microenv
 ironments is critical for determining the shape and pattern of tissues. Mo
 st mammalian ectodermal appendages\, including hair follicles\, are formed
  from the 2D flat epithelial primordia called placodes. However\, how thes
 e flat disc structures eventually transform into a variety of unique 3D sh
 apes with patterned cellular organization remains largely unknown. We comb
 ined live imaging and single-cell transcriptomics to capture a dynamic cel
 l lineage progression and transcriptome changes in the entire epithelium o
 f the mouse hair follicle as it develops. By following single-cells over t
 ime\, we found that hair placodes are organized into concentric rings of p
 rogenitor cell populations\, which telescope out to form longitudinally al
 igned 3D cylindrical functional compartments. Prospective hair follicle st
 em cells are derived from the peripheral ring of the placode basal layer\,
  where the characteristic state of adult hair follicle stem cells is obser
 ved. Combining these findings with previous work on the development of app
 endages in insects\, we provide the ‘telescope model’ for the developm
 ent of mammalian surface ectodermal organs. To further investigate how ext
 racellular matrix dynamics is involved in this process\, we established a 
 live imaging system that allows us to visualise and quantify basement memb
 rane dynamics together with multicellular dynamics. In this talk\, I will 
 discuss the mechanisms coupling skin organogenesis with signal and cellula
 r compartmentalization during dynamic morphogenetic events.
LOCATION:Online
END:VEVENT
END:VCALENDAR