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SUMMARY:Third-generation approaches of antibody discovery and optimisation
  - Dr Pietro Sormanni\, Department of Chemistry\, University of Cambridge
DTSTART:20231013T113000Z
DTEND:20231013T123000Z
UID:TALK206320@talks.cam.ac.uk
CONTACT:116482
DESCRIPTION:Abstract\n\nAntibodies play a crucial role as reagents in rese
 arch and diagnostics\, and are a key class of therapeutics. However\, curr
 ent technologies for antibody discovery and optimization are still subject
  to limitations. Established screening procedures are laborious and severa
 l hard-to-target antigens exist. Similarly\, targeting predetermined epito
 pes and optimizing multiple biophysical traits simultaneously remains a ch
 allenge. I will discuss emerging technologies of computational antibody de
 sign\, which enable the targeted design of antibodies for predetermined ep
 itopes and the prediction and modulation of their developability potential
 \, through the optimisation of multiple biophysical properties. Overall\, 
 it is increasingly possible to complement well-established in vivo (first 
 generation) and in vitro (second generation) methods of antibody discovery
  with in silico (third generation) approaches\, which provide time and cos
 t-saving benefits and increased precision. These approaches are becoming s
 ufficiently mature to be highly competitive for some applications\, thus o
 ffering novel opportunities to streamline antibody development.\n\nBiograp
 hy\n\nPietro Sormanni is a University Research Fellow supported by the Roy
 al Society. He leads a research group at the University of Cambridge that 
 sits at the interface between computation and in vitro experiments. Their 
 research is primarily focused on the development and validation of innovat
 ive technologies for computational antibody design\, aimed at transforming
  the ways antibodies are currently discovered and optimised. Through numer
 ous collaborations and industrial partnerships\, their work has demonstrat
 ed the potential for computational approaches to complement established pr
 ocedures and streamline antibody development\, offering novel\, time- and 
 cost-effective alternatives. Prior to his current position\, Pietro held a
  postdoctoral Borysiewicz Biomedical Sciences Fellowship from the Universi
 ty of Cambridge\, obtained a PhD in Chemistry\, and an MSc in Theoretical 
 Physics.\n\nZoom Link: https://zoom.us/j/97037774493?pwd=Rlh3YXA5VHk5cEdGd
 lIwUzJWdzNhdz09\n\nMeeting ID: 970 3777 4493\n\nPasscode: kYZ4LEU6JU
LOCATION:Seminar Room (Level 2)\, Dept of Pharmacology   Join online:  htt
 ps://zoom.us/j/94037796809?pwd=MHNRUk5JL0JmTlZTcnJZU3VQNllYQT09    
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