BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Exploiting nuclear envelope dysfunction in progeria to identify ne
 w therapeutic targets for ageing - Dr Delphine Larrieu\, Department of Pha
 rmacology\, University of Cambridge
DTSTART:20231020T113000Z
DTEND:20231020T123000Z
UID:TALK206329@talks.cam.ac.uk
CONTACT:116482
DESCRIPTION:Biography\n\nDr Delphine Larrieu has been a Wellcome Trust Sir
  Henry Dale fellow and a Group Leader at the University of Cambridge since
  2017. She initially set up her lab at the CIMR where she stayed for 5 yea
 rs\, and she was then appointed Assistant Professor in the Department of P
 harmacology\, where she relocated in October 2022.\n\nAfter working on tum
 our suppressor genes during her PhD at the University Grenoble Alpes (Fran
 ce)\, she developed a strong interest in the mechanisms linking nuclear en
 velope dysfunction with ageing and premature ageing syndromes (progerias) 
 during her postdoctoral training in Steve Jackson's lab at the Gurdon Inst
 itute - Cambridge.  \n\nHer work has focused on the identification of new 
 markers and modulators of nuclear envelope integrity\, to unravel the mech
 anisms underlying nuclear envelope dysfunction\, improve our understanding
  of premature and physiological ageing and contribute to the development o
 f novel therapies. She has developed pioneering approaches based on the pr
 inciple of synthetic rescue and relying on cutting-edge genetic screening 
 approaches\, and identified novel\, unexpected targets and cellular pathwa
 ys that can reverse several age-related nuclear envelope phenotypes. Her c
 urrent efforts are focused on characterising and expanding the number of t
 argets that can be exploited therapeutically to extend health and lifespan
  in progeria syndromes as well as in ageing.  \n\nDr Larrieu is a co-found
 er of Adrestia Therapeutics – recently acquired by Insmed – a syntheti
 c rescue company whose aim of restoring cellular balance in genetic diseas
 es was directly inspired by her work.  \n\nZoom link: https://zoom.us/j/94
 068850972?pwd=YmJoRTQ2NUZDRFNHWXd2R0FDc0hUUT09\n\nMeeting ID: 940 6885 097
 2\n\nPasscode: uY27KQv8cu
LOCATION:Seminar Room (Level 2)\, Dept of Pharmacology 
END:VEVENT
END:VCALENDAR