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SUMMARY:A novel mechanism of selective inhibition of Glycine receptors obs
 erved by Cryo-EM | Controlling and combining signal activation for adhesio
 n and receptor bridging - Speaker to be confirmed
DTSTART:20231117T123000Z
DTEND:20231117T133000Z
UID:TALK206347@talks.cam.ac.uk
CONTACT:116482
DESCRIPTION:Dr Stephanie Nestorow (Miller lab)\, Department of Pharmacolog
 y\, University of Cambridge\n\nBiography\n\nDr Nestorow completed their Ph
 D at the University of Birmingham under the guidance of Professor Tim Daff
 orn focusing on using SMALPs for the polymer purification of difficult mem
 brane proteins. During her PhD\, their research focused on the development
  and characterisation of several novel polymers which were then utilised t
 o study membrane proteins of agrochemical significance. During the PhD\, t
 hey gained an aptitude for a variety of biochemical and biophysical techni
 ques to investigate protein structure and function.\n\nBased on her experi
 ence purifying and characterising membrane proteins\, they began my post-d
 oc position within the Miller lab in December 2023. During their first yea
 r in the Miller lab\, they worked on both GABA and glycine receptors. Her 
 current research focuses on firstly\, using Cryo-EM based structural techn
 iques to decipher novel mechanisms of selective inhibition of Glycine rece
 ptors. Secondly\, studying the structural basis of small molecule and toxi
 n/antibody modulation of GABA receptors.\n\nDr Anthony Keeble (Howarth lab
 )\, Department of Pharmacology\, University of Cambridge\n\nBiography\n\nA
 nthony did a PhD and post-doc with Professor Colin Kleanthous first at the
  University of East Anglia and then at the University of York where he app
 lied biochemical and biophysical approaches to understand the mechanisms o
 f inhibitor binding to protein toxins. Subsequently\, Anthony used a combi
 ned structural\, biochemical\, and biophysical approach to understand immu
 ne receptor complex formation. Anthony used these studies to: (i) characte
 rise the interactions of TRIM21\, a novel intracellular IgG receptor\, wit
 h antibodies at the Laboratory of Molecular Biology\, Cambridge working wi
 th Dr Leo James\; (ii) characterise the formation and mechanism of activat
 ion of the activating complexes of the classical (C1qrs) and lectin (MBL-M
 ASP) pathways of complement at the Department of Respiratory Sciences\, Un
 iversity of Leicester working with Professor Russell Wallis\; (iii) charac
 terise the mechanism of formation of receptors (FceRI and CD23) with the a
 llergy related antibody IgE\, as well as the influence of anti-IgE Fab bin
 ding at the Randall Division of Cell and Molecular Biophysics\, King’s C
 ollege London working with Professor Brian Sutton and Professor James McDo
 nnell. Anthony is now working with Professor Mark Howarth within the Depar
 tment of Pharmacology\, University of Cambridge developing the novel prote
 in coupling reagents: SpyTag/SpyCatcher\, SnoopTag/SnoopCatcher\, DogTag/D
 ogCatcher\, SnoopLigase\, as well NeissLock that have a wide-range of appl
 ications: vaccines targeting COVID\, malaria\, and HIV\; split chimeric an
 tigen receptor-modified T cells\, protein hydrogels\, construction of anti
 body like molecules with controlled architectures\, labelling bacterial ou
 ter membrane proteins to measure membrane dynamics\, as well as selective 
 labelling mammalian ion channels.\n\nZoom link: https://zoom.us/j/92268391
 484?pwd=ajBET1FHbUJJWEdzL1hQWkREcFFRZz09\nMeeting ID: 922 6839 1484\nPassc
 ode: CeWtVvM68d
LOCATION:Seminar Room (Level 2)\, Dept of Pharmacology 
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