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SUMMARY:Phase Separation as a Stress Survival Strategy:  Stress Protection
  by Translation Factor Condensates - Prof. Simon Alberti\, Technical Unive
 rsity Dresden\, Germany
DTSTART:20231011T140000Z
DTEND:20231011T150000Z
UID:TALK207067@talks.cam.ac.uk
CONTACT:Ritwick Sawarkar
DESCRIPTION:Biomolecular condensates formed by phase separation on have ma
 jor roles in cellular organization on and physiology. RNP granules are a s
 pecific type of condensate that assemble from RNA-binding proteins and RN
 A. In this talk\, I will discuss how the concept of biomolecular condensat
 es has expanded our view of RNP granules and their link to the cellular st
 ress response. I will introduce in vitro reconstitution on systems based o
 n the concept of phase separation on that now allow us to reconstruct RNP
  granules in the test tube. Using these reconstitution on systems as well 
 as cell biological and genetic approaches\, we have gained important insi
 ghts into the molecular rules of RNP granule assembly\, such as the drivi
 ng forces and amino acids that govern condensates on\, the conformational
  changes underlying assembly and molecular mechanisms of condensate regul
 ation and control. I will further discuss how the concept of biomolecular
  condensates has allowed us to dissect the functions of RNP granules\, an
 d I will demonstrate how condensate formation can be used by cells to sen
 se and respond to changes in the environment and regulate fundamental cell
 ular processes such as protein synthesis.\n
LOCATION:Seminar Room\, Gleeson Building\, MRC Toxicology Unit\, Tennis Co
 urt Road
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