BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:CMV 2b silencing suppressor disrupts jasmonic and salicylic acid s
 ignalling - Alex Murphy
DTSTART:20091127T130000Z
DTEND:20091127T133000Z
UID:TALK20709@talks.cam.ac.uk
CONTACT:15560
DESCRIPTION:The 2b counter-defense protein of cucumber mosaic virus (CMV) 
 disrupts plant anti-viral mechanisms mediated by RNA silencing and salicyl
 ic acid (SA).  Biosynthesis of SA increased sharply in susceptible plants 
 infected with CMV\, a phenomenon usually associated with plant resistance 
 to pathogens.  However\, SA biosynthesis was not elicited in plants infect
 ed with the 2b gene deletion mutant CMV∆2b\, or in plants constitutively
  expressing the 2b protein.  JA levels were unaffected by either CMV or CM
 V∆2b.  Microarray data gathered in our lab showed that the 2b protein in
 hibited changes in the expression of 90% of the many genes regulated by ja
 smonic acid but had few effects on SA-regulated gene expression. JA is an 
 important signal in defense against insects and certain microbes but not a
 gainst viruses.  Our findings suggest that the 2b protein has evolved to m
 odify not only SA-mediated antiviral signaling\, but also to disrupt JA-me
 diated defenses.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
END:VEVENT
END:VCALENDAR