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SUMMARY:Evolution of endocellular trafficking in the eukaryotes: tethers\,
  retromer and factors affecting the shape of the ER - Lila Koumandou
DTSTART:20231024T110000Z
DTEND:20231024T120000Z
UID:TALK207151@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:Endomembrane system compartments are characteristic of eukaryo
 tic cells\, supporting functions including protein synthesis\, post-transl
 ational modifications and protein/lipid targeting. As such\, the endomembr
 ane system has important roles in signalling\, and defective vesicle trans
 port is associated with a variety of diseases. While these functions are m
 ostly studied in an evolutionarily narrow sampling of model organisms\, co
 mparative genomics can be used to examine the system in non-model organsis
 ms and to trace proteins and cellular traits to their roots. What has emer
 ged from these studies is that the origin of these compartments can be tra
 ced back to the origin of the eukaryotic cell\, which is estimated to have
  occurred over one billion years ago\, indicating spectacular cellular com
 plexity prior to expansion of the eukaryotic lineages. This provides a cha
 llenge in terms of explaining how these early eukaryotes arose. These stud
 ies also highlight that complexity can arise in multiple ways during evolu
 tion. The patterns of complexity generation will be illustrated by example
 s from studies of the tethering complexes (mediating vesicle fusion specif
 icity)\, the retromer complex (involved in retrograde traffic from the end
 osome or lysosome to the Golgi complex)\, and factors shaping the endoplas
 mic reticulum.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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