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SUMMARY:A new phase in structural biology - Prof Dame Carol V Robinson\, U
 niversity of Oxford
DTSTART:20231018T133000Z
DTEND:20231018T143000Z
UID:TALK207247@talks.cam.ac.uk
CONTACT:Vaidehi Roy Chowdhury
DESCRIPTION:While cryo-EM has transformed our view of the structures of pr
 otein assemblies\, behind the scenes gas phase structural biology has been
  emerging. Over a number of decades mass spectrometrists have revealed tha
 t the folding and topology of protein complexes can be retained in the gas
  phase\, if appropriate experimental parameters are applied.  These discov
 eries led to early compelling studies of antibody-antigen complexes\, viru
 ses\, ribosomes and molecular chaperones. More recently ‘snapshots’ of
  membrane protein complexes in the gas phase have been particularly enligh
 tening. Widely considered the most challenging of protein complexes\, but 
 yet the most important given their physiological roles\, the gas phase tur
 ns out to be an excellent medium in which to interrogate hydrophobic membr
 ane proteins. When encased in detergent micelles\, or other membrane mimet
 ics\, the effects of lipids on stability\, conformational change\, dynamic
 s and protein interactions are revealed. As such\, mass spectrometry is in
 forming membrane embedded efflux pumps (often implicated in antibiotic res
 istance mechanisms) assembly of membrane protein interfaces (primarily in 
 solute carriers) and receptor mediated signalling pathways (typically of G
 PCRs). In this lecture I will trace the history of these developments usin
 g selected highlights to illustrate progress made to date. Finally\, I wil
 l describe exciting future developments - soon to be realised….. 
LOCATION:Department of Chemistry\, Pfizer Lecture Theatre
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