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SUMMARY:Investigating host-parasite interactions in malaria to improve dia
 gnostics and treatments - Prof Aubrey Cunnington - Imperial College London
DTSTART:20231206T140000Z
DTEND:20231206T150000Z
UID:TALK207316@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Severe malaria has a mortality rate of 10-20% despite antimala
 rial treatment\, resulting in about 600\,000 deaths every year\, mostly ch
 ildren in sub-Saharan Africa. Despite extensive research on treatments to 
 reduce this mortality rate\, there are no proven effective treatments whic
 h can be added to antimalarials to save lives. One reason for this may be 
 an over-simplified view of the pathogenesis of severe malaria. A second re
 ason may be a lack of specificity in the diagnosis of severe malaria – w
 ith many cases actually having an alternative or additional cause of their
  life-threatening illness. Aubrey Cunnington’s group have used transcrip
 tomics to understand the host-parasite interactions driving malaria pathog
 enesis\, to identify translationally-relevant model systems for pre-clinic
 al testing of adjunctive treatments\, and as a novel approach to diagnosis
 . In this seminar Aubrey will outline key findings from these studies and 
 will explain how they are being translated into the next generation of dia
 gnostic and prognostic tests for malaria.
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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