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SUMMARY:Host manipulation by the parasite _Cryptosporidium_ - Dr Amandine 
 Guérin - Assistant Professor\, Department of Microbiology and Molecular M
 edicine\, University of Geneva\, Switzerland
DTSTART:20240424T130000Z
DTEND:20240424T140000Z
UID:TALK207334@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Infection by the parasite _Cryptosporidium_ is a leading cause
  of child mortality\, no vaccine is available and the current drug treatme
 nt against this diarrheal pathogen is inefficient. The disease is transmit
 ted through food or water contaminated with oocysts\, the chlorine-resista
 nt parasite stage. The parasite infects the epithelial cells of the small 
 intestine in which it replicates intracellularly. Invasion and intracellul
 ar development require extensive modifications of the host cell that remai
 n largely unknown at the molecular level. We recently showed that parasite
  secreted proteins play an important role in this process\, however\, our 
 knowledge remains limited. Modifications of the enterocytes as well as per
 sistent inflammation will alter the physiology of the gut and have long la
 sting impact on the children. In collaboration with Ross Waller laboratory
 \, we conducted a proteomic experiment\, hyperLOPIT\, on fractionated _Cry
 ptosporidium_ sporozoites to identify the content of the various secretory
  organelles. This list of potential _Cryptosporidium_ virulence factors wi
 ll help fill important gaps in our knowledge of the host/parasite interpla
 y.
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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