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SUMMARY:Young at heart: new strategies for accelerating regeneration - Pro
 fessor Nadia Rosenthal The Jackson Laboratory\, Bar Harbor Maine US\, Nati
 onal Heart and Lung Institute\, Imperial College London UK
DTSTART:20231017T153000Z
DTEND:20231017T163000Z
UID:TALK207436@talks.cam.ac.uk
CONTACT:Denise Hatherly
DESCRIPTION:What lies behind the remarkable potential of the body to rebui
 ld itself and why aren’t humans better at it? The limited restorative ca
 pacity of some tissues has been attributed to persistent inflammation with
  increasing age. Our approach has been to tinker with immune mechanisms at
  work in the mammalian response to damage\, disease and infection\, compar
 ed to other highly regenerative animals. Using combinations of genetic man
 ipulation and pharmacological blockades\, we have shown how modifying the 
 profile of immune cell infiltration can facilitate or prevent regeneration
  of heart and other tissues in mouse and axolotl\, an efficiently regenera
 ting member of the urodele amphibian family\, dependent on distinct differ
 ences in immune composition and response between species. Analysis of tiss
 ue regeneration amongst diverse mouse populations has also uncovered surpr
 ising variation that mimics the broad spectrum of sterile and infectious i
 mmune response and reparative trajectories in human patients. The diverse 
 regenerative capacity of adult mammalian organs is further reflected in th
 eir cell composition and transcriptomic profiles\, highlighting the potent
 ial for more genetically precise\, tissue-specific treatments. These studi
 es support the feasibility of intervening with our own incomplete response
  to injury\, infection or disease as we age\, reducing the impediments to 
 effective regeneration and providing new targets for clinical intervention
 .
LOCATION: Heart and Lung Institute\, Cambridge Biomedical Campus
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