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SUMMARY:Single-Cell and Spatial Dissection of Plant-Microbe Interactions  
 - Tatsuya Nobori\, PhD Salk Institute for Biological Studies
DTSTART:20231106T140000Z
DTEND:20231106T150000Z
UID:TALK207970@talks.cam.ac.uk
CONTACT:Sainsbury Laboratory
DESCRIPTION:In multicellular organisms\, individual cells interpret a mult
 itude of developmental and environmental signals through unique gene regul
 atory mechanisms\, leading to highly diverse cellular responses. A compreh
 ensive understanding of tissue function necessitates investigating these c
 omplex and heterogeneous gene regulatory patterns\, all while maintaining 
 the native three-dimensional (3D) tissue context. In this seminar\, I will
  cover two main topics: (1) the use of single-cell multiomics and spatial 
 transcriptomics in studying spatiotemporal dynamics of gene regulatory mec
 hanisms at the single-cell resolution in the model plant Arabidopsis thali
 ana\, and (2) the development of PHYTOMap\, a novel method for multiplexed
  single-cell 3D spatial gene expression analysis in whole-mount plant tiss
 ue. I will present how these methodologies allow for unprecedented resolut
 ion in studying interactions between plants and microbes.
LOCATION:Online (Zoom meeting). Contact events@slcu.cam.ac.uk for meeting 
 joining details. 
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