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SUMMARY:Tools and Tactics for Targeting RNA with Small Molecules - John 'J
 ay' Schneekloth\, Jr.\, Ph.D. from NIH/NCI
DTSTART:20231205T140000Z
DTEND:20231205T150000Z
UID:TALK208123@talks.cam.ac.uk
CONTACT:Echo Wu Williamson
DESCRIPTION:Despite the fact that some 85% of the human genome is transcri
 bed into RNA\, just 3% of these sequences code for proteins. Moreover\, ju
 st 15% of the human proteome is thought to be “druggable” with current
  methods. Coupled with extensive genome-wide association studies that indi
 cate RNA as a driver of diverse diseases\, these observations lead to the 
 idea that small molecules capable of targeting RNA could be powerful thera
 peutics for diverse diseases with no cure. In this seminar\, I will discus
 s our laboratory’s efforts to understand targeting RNA with small molecu
 les. This includes our work using a small molecule microarray (SMM) high t
 hroughput screening platform coupled with machine learning approaches to c
 haracterize RNA-binding chemical space\, development of chemical probes an
 d structure-guided design on RNA\, and examples of how to target mRNAs of 
 “undruggable” oncogenes.
LOCATION:Department of Chemistry\, Cambridge\, Wolfson Lecture Theatre
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