BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Sugars &amp\; proteins - Benjamin G. Davis The Rosalind Franklin I
 nstitute and University of Oxford
DTSTART:20231129T150000Z
DTEND:20231129T160000Z
UID:TALK208126@talks.cam.ac.uk
CONTACT:Echo Wu Williamson
DESCRIPTION:Our work studies the interplay of biomolecules – proteins\, 
 sugars\, lipids and their modifications. Synthetic Biology’s development
  at the start of this century may be compared with Synthetic Organic Chemi
 stry’s expansion at the start of the last\; after decades of isolation\,
  identification\, analysis and functional confirmation\, the future logica
 l and free-ranging redesign of biomacromolecules offers tantalizing opport
 unities to dissect mechanism and control function in physiology and biolog
 y.\nThis lecture will cover past and emerging areas in our group in the ma
 nipulation of biomolecules with an emphasis on new bond-forming and bond-b
 reaking processes compatible with biology and using those to understand mo
 lecular mechanisms.\n:\n(i) New methods: the development of precise method
 s that may be applied to biology at a posttranslational level\, generating
  minimal ‘scars’ or ‘traces’ (ideally ‘trace’-less)\, could al
 low broad control of function. This will allow applications beyond simple 
 ‘labeling biology’ or retrieval biology’. The development of chemo- 
 and regio-selective methods with potential to posttranslationally ‘edit
 ’ biology in this way\, applied under benign conditions to redesign and 
 reprogramme the structure and function of biomolecules\, will be presented
 .\n(ii) ‘Synthetic Biologics’ and their applications: biomimicry\; fun
 ctional recapitulation\; effector [drug/agrochemical/gene/radio-dose] deli
 very\; selective protein degradation\; inhibitors of pathogen interactions
 \; non-invasive presymptopmatic disease diagnosis\; probes and modulators 
 of in vitro and in vivo function illustrate possible resulting technologie
 s. \n
LOCATION:Department of Chemistry\, Cambridge\, Wolfson Lecture Theatre
END:VEVENT
END:VCALENDAR