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SUMMARY:Human lung organoid models of lung development and disease - Emma 
 Rawlins\, The Gurdon Institute/PDN\, Univeristy of Cambridge
DTSTART:20231207T160000Z
DTEND:20231207T170000Z
UID:TALK208333@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Organoids derived from primary human tissues retain key functi
 onal characteristics of the tissue of interest and have the potential to i
 mprove in vitro assays used for disease modelling and drug development. Ho
 wever\, the burgeoning CRISPR toolkits have not yet been widely applied to
  human organoids. We have developed efficient methodologies for the use of
  CRISPR techniques in primary human embryonic lung organoids. These will b
 e widely adaptable to other human organoid systems and include homology di
 rected repair\, CRISPRi\, CRISPRa and drop-out screens. This talk will ill
 ustrate how we have applied these systems to develop new human lung organo
 id models for fundamental developmental biology and disease research. 
LOCATION:Hodgkin Huxley Seminar Room\, Physiology builiding\, Downing Site
  CB2 3EG
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