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SUMMARY:Branching morphogenesis (talk held in small lecture theatre at the
  cavendish not the INI) - Ben Simons (University of Cambridge)
DTSTART:20231117T140000Z
DTEND:20231117T150000Z
UID:TALK208735@talks.cam.ac.uk
DESCRIPTION:The mechanisms that specify the complex organization of branch
 ed tissues has been the subject of long-standing debate. Although much is 
 known about the molecular programmes that control the underlying cell fate
  decisions\, it remains unclear how macroscopic features of branched organ
 s\, including their size\, ductal network topology and spatial pattern are
  encoded. Based on large-scale three-dimensional reconstructions of the de
 veloping mouse mammary gland and kidney epithelium\, we show that statisti
 cal features of branched epithelia can be explained quantitatively through
  a local self-organizing principle based on the branching and annihilating
  random walk (BARW). We discuss emergent features of the BARW model and it
 s generalizations to different branching contexts\, and we contrast its be
 haviour to more stereotypic branching programmes. Finally\, we highlight h
 ow the problem of branching morphogenesis provides a vivid illustration of
  how concepts and approaches from non-equilibrium statistical theory and a
 ctive matter physics may find impact in the realm of developmental biology
 .
LOCATION:External
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