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SUMMARY:Protein allostery as an illustration of an ensemble approach towar
 ds understanding biological function - Andrea Liu (University of Pennsylva
 nia)
DTSTART:20231208T113000Z
DTEND:20231208T120000Z
UID:TALK208891@talks.cam.ac.uk
DESCRIPTION:We know from statistical physics that we need ensembles in ord
 er to extract microscopic understanding of collective phenomena. We have d
 esigned central-force spring networks to have a function inspired by prote
 in allostery\, in which a strain applied locally gives rise to a comparabl
 e local strain at a distant location. By analyzing an ensemble of networks
  designed to have the similar response\, we find that the response is of a
  topological nature and can be characterized using persistent homology. Ou
 r analysis shows that allostery does not arise from discrete mechanisms bu
 t rather a continuum. Application of the persistent homology analysis to r
 eal proteins shows similar results.
LOCATION:Seminar Room 1\, Newton Institute
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