BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Mapping DNA replication stress in cancer cells and parasites with 
 long-read sequencing and AI - Dr Michael Boemo
DTSTART:20240222T160000Z
DTEND:20240222T170000Z
UID:TALK208999@talks.cam.ac.uk
CONTACT:Samantha Noel
DESCRIPTION:Every time a cell divides\, it must replicate its genome exact
 ly once\, which it achieves through the parallel action of replication for
 ks. The frequent slowing or stalling of replication forks\, termed “repl
 ication stress”\, is common in both cancer cells and parasites. Replicat
 ion stress is therefore a common therapeutic target for anti-malarial and 
 cancer chemotherapies\, but we have a relatively poor understanding of whe
 re\, when\, why\, and how often replication forks stall under these therap
 ies. I will discuss our recent progress towards answering these questions\
 , whereby we are using long-read nanopore DNA sequencing together with AI 
 to measure the movement and stress of thousands of replication forks acros
 s the genomes of human cancer cells and malaria parasites.\n
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
END:VEVENT
END:VCALENDAR