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SUMMARY:Identifying therapeutic opportunities in the metabolic crosstalk b
 etween the tumour and the host - Professor Karen Vousden\, The Francis Cri
 ck Institute
DTSTART:20240905T120000Z
DTEND:20240905T130000Z
UID:TALK209944@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Karen Vousden\, Loic Mervant\, Vassilis Papalazarou and Eric C
 heung\n\nThe Francis Crick Institute\, London NW1 1AT\, UK\n\nThe environm
 ent in which a cancer develops has a significant impact on the success of 
 malignant progression and will determine the requirements and vulnerabilit
 ies of the tumour\, particularly as the environment changes during metasta
 tic dissemination. We have been exploring the how metabolic changes and in
 creased ROS in cancer cells drive both cell intrinsic and cell extrinsic e
 ffects\, to promote tumour-supporting alterations in the tumour microenvir
 onment (TME). Tumour-derived signals also affect whole body metabolism to 
 induce nutrient release from fat and muscle and to prime metastasis niches
  to be more welcoming to disseminating cancer cells. Understanding and mod
 ulating the crosstalk between the tumour and the body may lead to new ther
 apeutic options and provide novel circulating biomarkers to detect and fol
 low cancer development. \n
LOCATION:CRUK CI Lecture Theatre
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