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SUMMARY:Of Odour Plumes and Synchrotrons: Structure and Function of Neural
  Circuits - Andreas Schaefer
DTSTART:20240122T180000Z
DTEND:20240122T193000Z
UID:TALK210055@talks.cam.ac.uk
CONTACT:Drishtant Chakraborty
DESCRIPTION:A central aspect to computation in the brain is to elucidate h
 ow information is transformed by the neural circuits of brain regions\, ho
 w inputs are transformed to outputs. Here\, I will discuss how we approach
  this work in the mouse olfactory system. Odours in natural settings are t
 ransported by complex\, often turbulent airflows. I will discuss the infor
 mation that is contained in the spatiotemporal odour plume structure\, how
  it is represented in the mammalian brain\, and how this can be accessed b
 ehaviourally. We will then use these rich odour stimuli to probe represent
 ation and processing across brain areas. To link function to structure and
  directly elucidate how information is transformed in early sensory areas\
 , I will introduce correlative multimodal imaging approaches\, centring ar
 ound different synchrotron X-ray tomography techniques. These enable us to
  directly identify the anatomy of neurons previously functionally imaged i
 n vivo across mm3 volumes. Specifically\, it allows us to identify output 
 channels corresponding to a given input channel in the olfactory bulb. The
 reby we can resolve how different “sister” projection neurons differen
 tially represent the external sensory world. Finally\, I will discuss how 
 such X-ray tomography methods can be developed to enable multimodal imagin
 g of mm3 tissues with synaptic resolution\, paving the way for dissecting 
 neural circuit anatomy across brain areas in a scalable way.  \n
LOCATION:Pfizer Lecture Theatre\,  Department of Chemistry\, Lensfield Roa
 d
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