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SUMMARY:Folding a Protein: Nature’s Origami - Prof Sheena Radford
DTSTART:20240314T180000Z
DTEND:20240314T193000Z
UID:TALK210085@talks.cam.ac.uk
CONTACT:Drishtant Chakraborty
DESCRIPTION:Proteins are amazing three-dimensional machines that carry out
  life’s essential processes. Modern methods in structural biology are en
 abling us to see these structures at work in ever-increasing molecular det
 ail\, and recent innovations in computational methods have revolutionised 
 our ability to design new proteins at will. Yet the most fundamental proce
 ss of all\, how proteins fold and assemble into complex machines\, remains
  mysterious. Errors of protein folding can give rise to devastating diseas
 es\, such as Alzheimer’s and Parkinson’s diseases and type II diabetes
 . Given the enormous burden of these\, and other\, disorders associated wi
 th protein misfolding\, understanding how folding’s fold has never been 
 more important. \n\nIn this lecture I will survey our current knowledge of
  protein folding\; discuss how Alphafold and other computational methods a
 re revolutionising our understanding of protein structure and behaviour\; 
 and share some of our newest discoveries in our quest to elucidate how pro
 teins misfold and cause disease. Progress in this field is moving apace\, 
 yielding a plethora of new discoveries\, enormous scientific excitement\, 
 and realistic hope that therapies to combat diseases of protein folding wi
 ll soon be within our grasp.\n
LOCATION:Pfizer Lecture Theatre\,  Department of Chemistry\, Lensfield Roa
 d
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