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SUMMARY:Flow and transport in the human placenta: a story with a twist - I
 gor Chernyavsky\, University of Manchester
DTSTART:20240315T160000Z
DTEND:20240315T170000Z
UID:TALK210223@talks.cam.ac.uk
CONTACT:Professor Grae Worster
DESCRIPTION:The human placenta is one of the most complex and unique organ
 s. It is a crucial life-support system that not only nourishes a growing f
 etus but also determines their lifelong health. The placenta is an exchang
 e organ with an intricate disordered micro-porous structure that packs a l
 arge surface area (~10 m^2) into a relatively thin disk\, attached to the 
 baby via a highly twisted umbilical cord. The talk will summarise recent p
 rogress in hyper-multiscale 3D imaging (spanning the range of µm to cm) a
 nd associated image-based mathematical modelling of placental transport. T
 he models explore the physics of flow- and diffusion-limited solute exchan
 ge and demonstrate a certain universality of upscaled approximations for a
  wide class of transported solutes. Finally\, we will discuss the surprisi
 ng role of the helical configuration of the umbilical cord in modulating s
 olute exchange\, and if time allows\, touch on moving beyond continuum mod
 els of transport.\n\nReferences:\n\nTun WM\, et al. (2021) J R Soc Interfa
 ce 18:20210140 (doi.org/10.1098/rsif.2021.0140).\n\nJensen OE & Chernyavsk
 y IL (2019) Annu Rev Fluid Mech 51:25 (doi.org/10.1146/annurev-fluid-01051
 8-040219).\n\nErlich A\, et al. (2019) Sci Adv 5:eaav6326 (doi.org/10.1126
 /sciadv.aav6326).\n\nChen Q\, et al. (2023) Soft Matter 19:5261 (doi.org/1
 0.1039/D3SM00208J).\n\n
LOCATION:MR2
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