BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:A novel type of proteasome condensates that can target toxic prote
 in aggregates - Dr Yu Ye\, Imperial College London\, Department of Brain S
 cience
DTSTART:20240301T160000Z
DTEND:20240301T170000Z
UID:TALK210364@talks.cam.ac.uk
CONTACT:Daniel Paolo Juan
DESCRIPTION:Dr Yu Ye\n\nImperial College London\, Department of Brain Scie
 nce\n\nBiography\n\nYu completed his PhD training in David Komander's lab 
 at MRC-LMB\, where they combined structural biology with biophysical\ntech
 niques to study molecular details of ubiquitin chains and deubiquitinases\
 , and interactions that underlaid regulation of the ubiquitin-proteasome s
 ystem (UPS). Following this\, Yu was fortunate to secure a stipendiary Jun
 ior Research Fellowship at Selwyn College followed by a Sir Henry Wellcome
  Research Fellowship\, to study the UPS with super-resolution imaging\ntec
 hniques. They worked between David Klenerman's group at Cambridge and Dani
 el Finley's group at Harvard to establish their own research direction\, f
 ocusing on using the UPS to remove protein aggregates. Notably\, their gro
 up demonstrated that large fibrillar aggregates can be directly broken up 
 by the 26S proteasome holoenzyme into small fragments in vitro in a ubiqui
 tin-independent manner\, defining a novel\, fibril-fragmenting function of
  proteasomes (Cliffe et al.\, Cell Rep. 2019).\n\nDuring this time\, they 
 also served as a Fellow and Director of Studies in Natural Sciences at Sel
 wyn. With a generous start-up package\, they moved to Imperial College Lon
 don to study the interplay between UPS and protein aggregation in neuronal
  models. Recently\, their group developed a quantitative super-resolution 
 imaging approach to measure the ability of pathological aggregates to pene
 trate cells\, showing that proteasomes respond to proteotoxicity within ho
 urs\, leading to aggregate removal (Morten et al.\,PNAS 2022). They are no
 w expanding these findings to characterise mechanisms underlying this aggr
 egate-induced proteasome response\, which we think is driven by condensati
 on of proteasomes and specific protein factors.\n\nVenue: Level 2 Seminar 
 Room\n\nZoom Link: https://cam-ac-uk.zoom.us/j/89654824601?pwd=QU9QNEVHVkJ
 SR0dVeVZ4VmovV2Uydz09\n\nMeeting ID: 896 5482 4601\n\nPasscode: 482026
LOCATION:Seminar Room (Level 2)\, Dept of Pharmacology 
END:VEVENT
END:VCALENDAR