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SUMMARY:Unravelling the impact of membrane transporters in cancer drug upt
 ake and efficacy - Dr Louise Fets MRC Investigator CRUK Career Establishme
 nt Awardee Drug Transport and Tumour Metabolism Lab Medical Research Counc
 il Laboratory of Medical Sciences (LMS)
DTSTART:20240207T150000Z
DTEND:20240207T160000Z
UID:TALK210406@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:For a drug to effectively engage its intended target\, it must
  be present at the correct concentration. In tumours\, poor vascularity im
 pacts drug availability. However\, once at the tumour site\, how drugs ent
 er cancer cells is often overlooked. Drug development has aimed to optimis
 e lipophilicity of compounds to ensure cell-permeability\, but increasing 
 evidence suggests that membrane transporters may also play an important ro
 le in drug uptake. In their endogenous role\, transporters regulate the pa
 ssage of metabolites across biological membranes and in cancer\, their exp
 ression patterns are highly heterogeneous. \n \nAs well as trying to under
 stand their role in cancer metabolism\, we are interested in whether heter
 ogeneity in transporter expression at the inter-patient level may contribu
 te to patient-to-patient differences in therapeutic response. In support o
 f this\, we have evidence that several drugs reach distinct steady state c
 oncentrations in cell lines with different transporter expression signatur
 es. At the intra-tumoural level\, using mass spectrometry imaging of patie
 nt-derived tumour explant models\, we have observed that drug uptake can a
 lso be heterogeneous\, and we are exploring whether these spatial differen
 ces in drug uptake could be an under-explored mechanism of drug resistance
 . \n
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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