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SUMMARY:Senescent secretome shenanigans:  Differential therapeutic benefit
  for breast cancer dictated by distinct extracellular vesicle-mediated inf
 lammatory response - Dr Karen Crasta\, Principal Investigator at the Natio
 nal University of Singapore\, Centre for Healthy Longevity and Department 
 of Physiology. 
DTSTART:20241017T120000Z
DTEND:20241017T130000Z
UID:TALK210511@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Triple-negative breast cancers\, associated with poor prognosi
 s and high tumour recurrence\, are often-treated with taxanes in first-lin
 e treatment regimens. However\, acquired disease resistance often sets in\
 , hampering clinical efficacy. Senescent cells represent a population of r
 esidual disease that is highly secretory and drives cancer relapse. Althou
 gh it is known that therapy-induced senescence can contribute to therapy r
 esistance and cancer relapse via its secretome\, the underlying cellular a
 nd molecular mechanisms are not fully understood. In this talk\, I will di
 scuss a recent study which uncovered an unexpected role for small extracel
 lular vesicles within the senescent tumour cell-derived secretome where th
 ey confer critical impact as discrete entities which mediate distinct anti
 -tumourigenic properties and inflammatory response.
LOCATION:CRUK CI Lecture Theatre
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