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SUMMARY:Echinoderm embryos to model epithelial morphogenesis: from cell bi
 ology to evo-devo - Vanessa Barone\, Hopkins Marine Station\, Biology Depa
 rtment\, Stanford University
DTSTART:20240205T143000Z
DTEND:20240205T153000Z
UID:TALK210901@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:*Abstract*: Embryos of many echinoderm species develop freely 
 in sea water with a fertilisation envelope as the only protection from env
 ironmental insults. In the sea star Patiria miniata the fertilisation enve
 lope not only protects\, but also helps shape the early embryo\, as the em
 bryonic cells form a blastula by lining the inner surface of the envelope.
  This raises the possibility that the spatial constraints imposed by the e
 nvelope may influence epithelial morphogenesis\, e.g. compaction\, cell de
 nsity and cell connectivity.\n\nWe used live-imaging of the sea star embry
 o coupled with deep learning-based segmentation\, to dissect the relative 
 contributions of cell density\, tissue compaction\, and cell proliferation
  on epithelial architecture. We found that the 3D connectivity of cells wi
 thin the tissue changes over time as epithelial compaction and cell densit
 y increase. Importantly\, these changes in 3D packing are due to the combi
 ned effects of cell division within the embryo and of the spatial constrai
 nts acting on the embryos. \n\nThese results raise interesting hypotheses 
 concerning the role of protective structures\, such as the fertilisation e
 nvelope\, in key aspects of embryonic development and its evolution. \n\nJ
 oin Zoom Meeting \n\n\nhttps://us06web.zoom.us/j/82089026611?pwd=L2FyclJFL
 2lYR0J3SFBDbHQyUFp6UT09 \n\n  \n\nMeeting ID: 820 8902 6611 \n\nPasscode: 
 038347 \n\n  \n
LOCATION:Online
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