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SUMMARY:Temporal patterning during development and tumorigenesis - Cedric 
 Maurange\, IBDM\, Marseille\,France
DTSTART:20240212T143000Z
DTEND:20240212T153000Z
UID:TALK210904@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:During embryogenesis\, stem cells first undergo a phase of amp
 lification which is followed by the unfolding of differentiation programs 
 ultimately leading to functional tissues with the correct number and diver
 sity of cell types. The mechanisms regulating the temporality of these dif
 ferent phases is not fully understood. Over the last decade\, studies have
  revealed in Drosophila an overarching temporal patterning system that sch
 edules the different phases of stem cell/progenitor self-renewal and diffe
 rentiation. I will describe how we have unveiled key players in this tempo
 ral patterning system and how they are regulated by different humoral\, lo
 cal or cell-intrinsic timing signals. I will also discuss our finding that
  temporal patterning delineates windows of malignant susceptibility in the
  developing brain and how its perturbation drives tumorigenesis upon vario
 us genetic insults. Finally\, I will show how\, using a combination of ima
 ge analysis and computer simulations\, we try to decipher the principles b
 y which temporal patterning cooption governs the hierarchy of brain tumors
 . Our work illuminates the links between development\, regeneration and tu
 morigenesis and provides a paradigm to understand cancers with development
 al origins.\n\nJoin Zoom Meeting \n\n\nhttps://us06web.zoom.us/j/820890266
 11?pwd=L2FyclJFL2lYR0J3SFBDbHQyUFp6UT09 \n\n  \n\nMeeting ID: 820 8902 661
 1 \n\nPasscode: 038347 \n\n
LOCATION:In person at PDN and online
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