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SUMMARY:Discovery and scale-up of a novel herbicide by Paul Burton from Sy
 ngenta - Syngenta
DTSTART:20240229T160000Z
DTEND:20240229T170000Z
UID:TALK211465@talks.cam.ac.uk
CONTACT:Chung Tu
DESCRIPTION:New herbicides are required to improve levels or spectrum of a
 ctivity\, to overcome resistance to existing products\, or to replace olde
 r products under regulatory pressure. The first part of the talk will desc
 ribe the discovery and optimization program for dioxopyritrione (Figure 1)
 \, a novel inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD) for use
  in wheat and barley.\nOnce a development candidate is identified\, a majo
 r issue is finding a safe\, scalable\, and cost-efficient synthesis. For t
 he synthesis of herbicides\, cost pressure is high and thus a major effort
  was required to reduce the cost of manufacturing. The second part of this
  talk will describe process research and development activities starting f
 rom the initial route scouting and ending with the scale-up in a pilot pla
 nt\, including a large-scale photochemical step.\n
LOCATION:Dept. of Chemistry\, Wolfson Lecture Theatre
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