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SUMMARY:Modelling Blood Cell Development across Molecular and Tissue Scale
 s - Bertie Gottgens\, Cambridge Stem Cell Institute
DTSTART:20240215T160000Z
DTEND:20240215T170000Z
UID:TALK211531@talks.cam.ac.uk
CONTACT:Samantha Noel
DESCRIPTION:A continuous flow of cells replenishes blood throughout life t
 o maintain hematopoietic homeostasis. This flow originates from hematopoie
 tic stem cells (HSCs) and progresses through a complex hierarchy of progen
 itors\, collectively called hematopoietic stem and progenitor cells (HSPCs
 ). The ever-increasing throughput of modern single cell ‘omics methods m
 eans that datasets encapsulating the cellular complexity of entire organ s
 ystems can now be generated. However\, ‘omics protocols deliver snapshot
  measurements\, because cells need to be destroyed to characterize their m
 olecular states. As a result\, it’s impossible to determine from those m
 easurements how long it takes for a given cell to complete a differentiati
 on process\, nor at which precise stages cell numbers expand or contract.\
 nNew research from Göttgens group provides a strategy to create predictiv
 e dynamic models of a regenerative organ in vivo\, at single cell resoluti
 on and over extended timeframes. The Göttgens team went on to use novel t
 ime-series datasets for blood development to generate new computational mo
 dels capturing the tissue dynamics of mouse bone marrow haematopoiesis. Th
 is allowed the coupling of cascading single-cell expression patterns with 
 dynamic changes in differentiation and growth speeds.\nChanges in tissue d
 ynamics underlie many major diseases\, such as ageing associated defects i
 n tissue maintenance and regeneration as well as clonal stem cell competit
 ion during early premalignant growth. To quantify such defects\, researche
 rs must first define tissue dynamics in the unperturbed healthy state. Thi
 s new work provides such critical information for the blood system.\n
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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