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SUMMARY:How innate immune cells adapt to environment and function: diverse
  tales of mitochondria - Stefanie Wculek\, IRB (Biomedical Research Instit
 ute\, Barcelona)
DTSTART:20240523T150000Z
DTEND:20240523T160000Z
UID:TALK211717@talks.cam.ac.uk
CONTACT:83896
DESCRIPTION:Innate immune cells\, such as macrophages and dendritic cells\
 , inhabit all body organs to detect danger and initiate immune responses a
 s well as to maintain organ health. However\, the mechanisms facilitating 
 those diverse functions of innate immune cells in distinct tissue milieus 
 are poorly understood.\n\nRecently\, we found tissue macrophages to engage
  their mitochondrial metabolism in an organ-specific manner. Mechanistical
 ly\, they adapt the activity of their mitochondrial electron transport cha
 in to handle large amounts of environmental lipids in homeostasis. This fu
 nctional dependence of tissue macrophages on mitochondrial metabolism can 
 be harnessed to ameliorate obesity-related pathologies. On the other hand\
 , innate immune cells have to quickly respond to insults and activate immu
 nity for containment\, in particular conventional dendritic cells. We disc
 overed a differential bioenergetic dependence of the immunogenic responsiv
 eness of type 1 versus type 2 dendritic cells (unpublished data). The dist
 inct engagement of mitochondrial metabolism regulates the epigenetic state
  and functional outputs of dendritic cell subsets and affects their potenc
 y to induce anti-cancer immunity.\n\nOverall\, my talk will focus on how m
 itochondria and an active electron transport chain regulate the context-de
 pendent functions of innate immune cells via entirely distinct molecular m
 echanisms.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology builiding\, Downing Site
  CB2 3EG
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