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SUMMARY:Identifying mechanisms of\, and countermeasures to\, muscle declin
 e in ageing - Dr Colleen Deane\, University of Southampton
DTSTART:20240606T150000Z
DTEND:20240606T160000Z
UID:TALK211720@talks.cam.ac.uk
CONTACT:83896
DESCRIPTION:2024 R Jean Banister Prize Lecture\, from the Physiological So
 ciety.\n\nSkeletal muscle is the largest organ in the body playing vital r
 oles in locomotion and metabolism. As we age\, we progressively lose muscl
 e mass and strength\, which increases the risk of frailty-related falls\, 
 morbidity and mortality. Ageing muscle also displays an impaired capacity 
 to fully adapt to current countermeasures e.g.\, resistance exercise (RE) 
 training (RET). \nDespite the socioeconomic significance of muscle decline
 \, the underlying mechanisms remain to be fully defined\, and fully effect
 ive countermeasures remain elusive. Using biologicallydriven transcriptio
 nal meta-analysis\, we identified altered mitochondrial networks to be ass
 ociated with muscle atrophy\, and extracellular matrix\, immune and inflam
 matory networks to be associated with impaired adaptation to RET in older 
 muscle. To rejuvenate the \nmitochondria\, we trialled the effects of a ni
 cotinamide adenine dinucleotide (NAD+) precursor\, \nnicotinic acid\, in o
 lder adults. We found that two weeks supplementation altered carbohydrate\
 , citric acid cycle and electron transport genes\, and upregulated NAD+ re
 lated\npathways\, indicating metabolic programming. Our results so far hav
 e identified molecular candidates for understanding and treating age-relat
 ed muscle decline.\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology builiding\, Downing Site
  CB2 3EG
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