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SUMMARY:CANCELLED - LMB Seminar: RNA Meets DNA: Dangerous Liaisons in the 
 Genome - Karlene Cimprich - Stanford University School of Medicine\, Depar
 tment of Biochemistry
DTSTART:20241003T093000Z
DTEND:20241003T103000Z
UID:TALK211876@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:R-loops are three-stranded nucleic acid structures that form c
 o-transcriptionally and which are comprised of an RNA-DNA hybrid and a dis
 placed strand of ssDNA. Although R-loops have important functions in cells
 \, their dysregulation can also lead to genome instability. We recently sh
 owed that a surprising consequence of dysregulated R-loop metabolism is th
 e release of RNA-DNA hybrid fragments into the cell and subsequent sensing
  of these hybrids by innate immune receptors. In this seminar I will descr
 ibe our recent studies demonstrating how these pathological R-loops arise 
 and features that cause them to threaten genome stability.
LOCATION:CANCELLED
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