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SUMMARY:Optimal information loading into working memory explains dynamic c
 oding in the prefrontal cortex - Adam Triabhall
DTSTART:20240208T150000Z
DTEND:20240208T160000Z
UID:TALK212056@talks.cam.ac.uk
CONTACT:Adam Triabhall
DESCRIPTION:This week we will discuss and debate a recent paper by Stroud 
 and colleagues\, published in PNAS (2023).\n\nAbstract: “Working memory 
 involves the short-term maintenance of information and is critical in many
  tasks. The neural circuit dynamics underlying working memory remain poorl
 y understood\, with different aspects of prefrontal cortical (PFC) respons
 es explained by different putative mechanisms. By mathematical analysis\, 
 numerical simulations\, and using recordings from monkey PFC\, we investig
 ate a critical but hitherto ignored aspect of working memory dynamics: inf
 ormation loading. We find that\, contrary to common assumptions\, optimal 
 loading of information into working memory involves inputs that are largel
 y orthogonal\, rather than similar\, to the late delay activities observed
  during memory maintenance\, naturally leading to the widely observed phen
 omenon of dynamic coding in PFC. Using a theoretically principled metric\,
  we show that PFC exhibits the hallmarks of optimal information loading. W
 e also find that optimal information loading emerges as a general dynamica
 l strategy in task-optimized recurrent neural networks. Our theory unifies
  previous\, seemingly conflicting theories of memory maintenance based on 
 attractor or purely sequential dynamics and reveals a normative principle 
 underlying dynamic coding” (Stroud et al.\, 2023).\n\nReference: Stroud\
 , J.P.\, Watanabe\, K.\, Suzuki\, T.\, Stokes\, M. G.\, & Lengyel\, M. (20
 23). Optimal information loading into working memory explains dynamic codi
 ng in the prefrontal cortex. PNAS\, 120(48)\, e2307991120. https://doi.org
 /10.1073/pnas.2307991120
LOCATION:https://cam-ac-uk.zoom.us/j/92612577704?pwd=MUtqMjVQdXNmUTVIYjRkM
 G1NUW9GZz09
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