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SUMMARY:Sticky feet: biophysical models for cell adhesion - Maria Tatulea-
 Codrean\, University of Cambridge
DTSTART:20240425T120000Z
DTEND:20240425T130000Z
UID:TALK212122@talks.cam.ac.uk
CONTACT:Marco Vona
DESCRIPTION:Almost all animal cells rely on actomyosin contractility as a 
 mechanism for cell migration (with the notable exception of sperm cells wh
 ich swim using undulating flagella). Oftentimes\, what enables the actomyo
 sin cortex to transmit forces to the extracellular environment and\, hence
 \, to generate directed motion is the adhesion of the cell to external str
 uctures. In fact\, cell adhesion is one of three key stages in the classic
 al description of 2D cell migration as a cycle of repetitive protrusion\, 
 adhesion and contraction.\n\nIn this talk\, we will introduce the basic bi
 ophysics of cell adhesion and its role in the well-studied migration of ce
 lls over 2D surfaces. Next\, we will present a recent mean-field model tha
 t describes the early formation of adhesion clusters (nascent adhesions) a
 s a phase separation of ligand-receptor bonds (the 'sticky feet' mentioned
  in the title). This model is motivated by recent experiments investigatin
 g the adhesion of cells to lipid bilayers enriched with ligands of differe
 nt affinities (or 'stickiness') [1]. If time allows\, we will end by discu
 ssing recent efforts to expand the notion of protein friction (a measure o
 f the adhesive strength between a moving cell and the substrate) to the ca
 se of cells migrating over complex substrates composed of both fluid and e
 lastic layers.\n\nReference:\n[1] Oleg Mikhajlov\, Ram M. Adar\, Maria Tă
 tulea-Codrean\, Anne-Sophie Macé\, John Manzi\, Fanny Tabarin\, Aude Batt
 istella\, Fahima di Federico\, Jean-François Joanny\, Guy Tran van Nhieu\
 , Patricia Bassereau\nbioRxiv 2022.09.12.507658\; https://doi.org/10.1101/
 2022.09.12.507658
LOCATION:MR15\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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