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SUMMARY:Self-assembled active actomyosin gels spontaneously curve and wrin
 kle similar to biological cells and tissues - Anne Bernheim\, Ben-Gurion U
 niversity of the Negev
DTSTART:20240516T120000Z
DTEND:20240516T130000Z
UID:TALK212197@talks.cam.ac.uk
CONTACT:Marco Vona
DESCRIPTION:Living systems adopt a diversity of curved and highly dynamic 
 shapes. These diverse morphologies appear on many length-scales\, from cel
 ls to tissues and organismal scales. The common driving force for these dy
 namic shape changes are contractile stresses generated by myosin motors in
  the cell cytoskeleton\, that converts chemical energy into mechanical wor
 k. A good understanding of how contractile stresses in the cytoskeleton ar
 ise into different 3D shapes and what are the shape selection rules that d
 etermine their final configurations is still lacking. To obtain insight in
 to the relevant physical mechanisms\, we recreate the actomyosin cytoskele
 ton in-vitro\, with precisely controlled composition and initial geometry.
  A set of actomyosin gel discs\, intrinsically identical but of variable i
 nitial geometry\, dynamically self- organize into a family of 3D shapes\, 
 such as domes and wrinkled shapes\, without the need for specific pre-prog
 ramming or additional regulation. Shape deformation is driven by the spont
 aneous emergence of stress gradients driven by myosin and is encoded in th
 e initial disc radius to thickness aspect ratio\, which may indicate shapi
 ng scalability. Our results suggest that\, while the dynamical pathways ma
 y depend on the detailed interactions between the different microscopic co
 mponents within the gel\, the final selected shapes obey the general theor
 y of elastic deformations of thin sheets. Altogether\, our results emphasi
 ze the importance for the emergence of active stress gradients for bucklin
 g driven shape deformations and provide novel insights on the mechanically
  induced spontaneous shape transitions in contractile active matter\, reve
 aling potential shared mechanisms with living systems across scales.\nRele
 vant Publication:\nIdeses\, Y.\, ....\, ABG\, 2018\, Spontaneous buckling 
 of poroelastic actomyosin sheets\, Nature\nCommunications 6\, 2461-13\nLiv
 ne\, G.\, ....\, Bernheim-Groswasser\, A.\, 2024\, Self-assembled active a
 ctomyosin gels\nspontaneously curve and wrinkle similar to biological cell
 s and tissues. PNAS 121 e2309125121.\nABG\, ....\, Teresi\, L.\, 2024\, In
 terplay between activity\, elasticity and liquid transport in self- contra
 ctile biopolymer gels. Phys. Rev. E\, 109\, 014601
LOCATION:MR14\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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